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The proinflammatory phenotype is the dominant phenotype of immune cells in T2DM. In T2DM, M1 macrophages tend to be the dominant immune cells that bring about inflammation in islets.352,353,354 The expression levels of PPAR? in macrophages from T2DM patients are decreased, and macrophage-certain PPAR? controls M2 macrophage activation.355,356 The p